Your Digest for Monday, Apr 22, 2024 04:59 PM


Phase I - double digits (<100)
Phase II - Triple digits (<300)
Phase III - quadruple digits, also C being the 3rd letter of the alphabet, phase III trials 'compare' efficacy -> RCTs. (<3000)
3. Phamacokinetic testing to determine ADME characteristics (absorption, distribution, metabolism and elimination)
Phase 3 = 1000-3000 to confirm effectiveness, monitor side effects and compare with other treatments. (⭐therapeutic confirmation - Randomized controlled trials; efficacy, safety)

[!INFO] Mmemonic: Bag of flowers
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- **Tau protein** is a protein which stabilizes microtubules and regulates protein binding to microtubules in healthy cells. 

[!INFO] Tau causes Tangles; APP causes Plaques



Other causes of subtotal villous atrophy

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  1. AL amyloidosis <- The most common form.
    Other types of amyloidosis:

[!INFO] AL Vs AA : importance of differentiating
AL amyloidosis must be differentiated from other forms of amyloidosis (eg, AA amyloidosis, ATTRmt amyloidosis, and ATTRwt amyloidosis) since the latter are non-neoplastic and will not benefit from chemotherapy.

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[!INFO] Once the presense of amyloid is found
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the precursor protein must be determined.
(Both (AL and AA) have the beta pleted sheet structure) (Harrison's - page 804)

[!INFO] AL Amyloidosis and mutliple myeloma are closely related but NOT the same.


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Source
Pharmacological efficacy (also called Intrinsic efficacy) is


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[[2018-OCT-BSQ#Pulmonary vascular resistance]]


Pathophysiology of NAFLD

Insulin resistance is the key prerequisite for NAFLD.

  1. Dyslipidaemia (Low HDL and high TGL)